GÖRDÜK KAZASI’NIN DEMOGRAFİK YAPISI (1530-1575)
نویسندگان
چکیده
منابع مشابه
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The formin family proteins are important regulators of actin polymerization that are involved in many cellular processes. However, little is known about their specific cellular localizations. Here, we show that Diaphanous-related formin-3 (mDia2) localizes to the cytoplasmic side of the nuclear envelope. This localization of mDia2 to the nuclear rim required the presence of a nuclear localizati...
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Axitinib is an inhibitor of tyrosine kinase vascular endothelin growth factor receptors 1, 2, and 3. The ATP-binding cassette (ABC) and solute carrier (SLC) transport properties of axitinib were determined in selected cellular systems. Axitinib exhibited high passive permeability in all cell lines evaluated (Papp ‡ 6 3 10 cm/s). Active efflux was observed in Caco-2 cells, and further evaluation...
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Inhibition of cytochromes P450 by time-dependent inhibitors (TDI) is a major cause of clinical drug-drug interactions. It is often difficult to predict in vivo drug interactions based on in vitro TDI data. In part 1 of these manuscripts, we describe a numerical method that can directly estimate TDI parameters for a number of kinetic schemes. Datasets were simulated for Michaelis-Menten (MM) and...
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Over the past two decades, there has been an exponential and enthusiastic adoption of simulation in healthcare education internationally. Medicine has learned much from professions that have established programs in simulation for training, such as aviation, the military and space exploration. Increased demands on training hours, limited patient encounters, and a focus on patient safety have led...
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Pain perception is subject to powerful modulatory influences that can increase or reduce subjective responses in the short and long term. Nociceptive circuits can become sensitised causing both innocuous and noxious inputs to be amplified and their intensity and other sensory characteristics to be increased. Both central and peripheral mechanisms of sensitisation are recognised. Nociceptive mec...
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ژورنال
عنوان ژورنال: Celal Bayar Üniversitesi Sosyal Bilimler Dergisi
سال: 2016
ISSN: 2146-2844,1304-4796
DOI: 10.18026/cbusos.72918